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Clinical Pharmacology

Managed care approach to substance abuse treatment
An examination of people’s behaviors as they relate to drug use in the 20th century has shown that people will expend a large amount of energy to acquire any agent that has the ability to alter their minds, bodies, or behaviors in order to achieve a euphoric effect.
Seizure drug may turn skin blue
A medication used to treat seizures, ezogabine (Potiga, Valeant), can cause blue skin discoloration, the Food and Drug Administration (FDA) warns, and it is unknown whether the pigmentation changes are reversible.
Dabigatran as effective as warfarin to prevent VTE recurrence
Data from the RE-MEDY trial suggest that Pradaxa is as effective as warfarin for long-term, extended antithrombotic therapy in patients who have already received at least three months of anticoagulation for VTE
FDA approves 3 new therapies for type 2 diabetes
Alogliptin approved as monotherapy and in two combinations
FDA approval marks new drug class for type 2 diabetes
Canaglifozin (Invokana, Janssen Pharmaceuticals) tablets, recently approved by the U.S. Food and Drug Administration for the improvement of glycemic control in adults with type 2 diabetes, is the first diabetes treatment approved in a new class of drugs known as sodium-glucose co-transporter 2 inhibitors.
Guideline recommendations issued for molecular testing, targeted therapies in lung cancer
The College of American Pathologists (CAP), International Association for the Study of Lung Cancer (IASLC), and Association for Molecular Pathology (AMP) recently issued evidence-based guidelines on molecular testing in lung cancer, and support the recommendation that physicians conduct testing in advanced non-small cell lung cancer patients at the time of diagnosis or at the time of recurrence or progression.
First drug approved specifically for multi-drug resistant tuberculosis
FDA approved bed aquiline tablets late last year for the treatment of pulmonary multi-drug-resistant tuberculosis.
Apixaban added to anticoagulant arsenal
FDA recently approved apixaban for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
New strategies needed to reduce mortality associated with cardiometabolic risk factors in young people
Among US adolescents and young adults, HbA1c levels, central obesity, and smoking were associated with an increased risk of dying before 55 years of age.
Researchers seek next class of anti-allergics
Allergy season is almost upon us and anti-histamine agents remain the top choice. However, researchers are looking for new medications to help patients with different needs.
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