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Michael G Burke, MD
LCPUFAs in pregnancy lower child’s asthma risk
Women in the third trimester of pregnancy who take supplements of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) reduce their children’s risk of persistent wheeze or asthma as well as of lower respiratory tract infections, a study in Denmark demonstrated.
Meningococcal vaccine might raise risk of Bell’s palsy
In a study of almost 48,900 vaccinated individuals, investigators observed a temporal association between development of Bell’s palsy and administration of quadrivalent meningococcal conjugate vaccine (MCV4) that protects against serogroups A,C, Y, and W (MenACWY) when the vaccine was given at the same time as other vaccines.
Two-step egg introduction helps prevent egg allergy
Stepwise introduction of egg (starting with a low dose, which is then increased), along with aggressive treatment of atopic dermatitis (AD), is a safe and effective way to prevent hen’s egg allergy in high-risk infants, a study in Japan showed.
Top 10 studies you may have missed- 2017
It’s that time again! Here are Dr Michael Burke’s favorite 10 articles he reviewed in Journal Club for Contemporary Pediatrics during the past 12 months that are most likely to change your practice, improve patient care, or illuminate future trends in pediatrics.
How to evaluate young febrile infants
A large retrospective study of how infants with fever without a cause are evaluated found that physicians are selective in deciding which of these babies will have blood, urine, or cerebral spinal fluid cultures.
How best to reduce injection pain—lidocaine cream
A comparison of 4 levels of pain management of routine vaccine injections found that of the remedies tried, only liposomal lidocaine applied at the injection site provided consistent relief.
Limiting duration of antibiotics in OM limits their effectiveness
Treating children with acute otitis media with amoxicillin-clavulanate for 5 days is less effective than following standard 10-day treatment, according to a study in 520 such children who were aged 6 to 23 months.
Medication or placebo to prevent migraine?
A trial comparing amitriptyline, topiramate, and placebo for prevention of migraine in children and adolescents with a history of migraine found that all 3 had about the same effect on reducing headache frequency or headache-related disability.
Effective early autism intervention has long-term impact
A follow-up trial conducted 6 years after the conclusion of a randomized controlled trial of early intervention in autism spectrum disorder demonstrated that the intervention had a long-term effect on autism symptoms and continued effects on parent and child social interaction.
Overweight is not treated in children hospitalized with asthma
A retrospective record review for youngsters admitted with asthma to a Midwestern children’s hospital revealed that overweight and obesity were underrecognized, underdiagnosed, and undertreated.

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